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File:Illu connective tissues 1.jpg
"Adipose" redirects here. For the Doctor Who monster, see "Partners in Crime".

In histology, adipose tissue or fat is loose connective tissue composed of adipocytes. Adipose tissue is derived from lipoblasts. Its main role is to store energy in the form of fat, although it also cushions and insulates the body. Obesity or being overweight in humans and most animals does not depend on body weight but on the amount of body fat—specifically, adipose tissue. Two types of adipose tissue exist: white adipose tissue (WAT) and brown adipose tissue (BAT). Adipose tissue also serves as an important endocrine organ[1] by producing hormones such as leptin, resistin and the cytokine TNFα. The formation of adipose tissue appears to be controlled by the adipose gene.

Anatomical featuresEdit

In humans, adipose tissue is located beneath the skin (subcutaneous fat), and is also found around internal organs (visceral fat). Adipose tissue is found in specific locations which are referred to as 'adipose depots.' Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages and endothelial cells. Adipose tissue contains many small blood vessels. In the integumentary system, which includes the skin, it accumulates in the deepest level, the subcutaneous layer, providing insulation from heat and cold. Around organs, it provides protective padding. However, its main function is to be a reserve of lipids, which can be burned to meet the energy needs of the body. Adipose depots in different parts of the body have different biochemical profiles.

MiceEdit

In mice, there are eight major adipose depots, four of which are within the abdominal cavity: the paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males, the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and when massive extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen and when massive extends into the ventral abdomen. Both the mesenteric and omental depots incorporate much lymphoid tissue as lymph nodes and milky spots respectively. The two superficial depots are the paired inguinal depots, which are found anterior to the upper segment of the hind limbs (underneath the skin) and the subscapular depots, paired medial mixtures of brown adipose tissue adjacent to regions of white adipose tissue, which are found under the skin between the dorsal crests of the scapulae. The layer of brown adipose tissue in this depot is often covered by a “frosting” of white adipose tissue, sometimes these two types of fat (brown and white) are hard to distinguish. The inguinal depots enclose the inguinal group of lymph nodes. Minor depots include the pericardial which surrounds the heart, and the paired popliteal depots, between the major muscles behind the knees, each containing one large lymph node[2]. Of all the depots in the mouse, the gonadal depots are the largest and the most easily dissected[3], comprising about 30% of dissectible fat[4].

ObesityEdit

File:Central Obesity 008.jpg

In a severely obese person, excess adipose tissue hanging downward from the abdomen is referred to as a panniculus (or pannus). A panniculus complicates surgery of the morbidly obese. The panniculus may remain as a literal "apron of skin" if a severely obese person quickly loses large amounts of fat (a common result of gastric bypass surgery). This condition cannot be effectively corrected through diet and exercise alone, as the panniculus consists of adipocytes and other supporting cell types shrunken to their minimum volume and diameter. Reconstructive surgery is one method of treatment.

PhysiologyEdit

Free fatty acid is "liberated" from lipoproteins by lipoprotein lipase (LPL) and enters the adipocyte, where it is reassembled into triglycerides by esterifying it onto glycerol. Human fat tissue contains about 87% lipids.

In humans, lipolysis is controlled though the balanced control of lipolytic B-adrenergic receptors and a2A-andronergic receptor mediated antilipolysis.

Fat is not laid down when there is a surplus available and stored passively until it is needed; rather it is constantly being stored in and released from each cell.

Fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels, as well as determining insulin resistance. Abdominal fat has a different metabolic profile—being more prone to induce insulin resistance. This explains to a large degree why central obesity is a marker of impaired glucose tolerance and is an independent risk factor for cardiovascular disease (even in the absence of diabetes mellitus and hypertension).[citation needed]

Recent advances in biotechnology have allowed for the harvesting of adult stem cells from adipose tissue, allowing stimulation of tissue regrowth using a patient's own cells. The use of a patient's own cells reduces the chance of tissue rejection and avoids the ethical issues associated with the use of human embryonic stem cells.

Adipose tissue is the greatest peripheral source of aromatase in both males and females contributing to the production of estradiol.

Adipose derived hormones include:

Adipose tissues also secrete a type of cytokines (cell-to-cell signalling proteins) called adipokines (adipocytokines) which play a role in obesity-associated complications.

Brown fatEdit

A specialised form of adipose tissue in human infants, and some hibernating animals, is brown fat or brown adipose tissue. It is located mainly around the neck and large blood vessels of the thorax. This specialised tissue can generate heat by "uncoupling" the respiratory chain of oxidative phosphorylation within mitochondria, leading to the breakdown of fatty acids. This thermogenic process may be vital in neonates exposed to the cold, who then require this thermogenesis to keep warm as they are unable to shiver, or take other actions to keep themselves warm.[5]

Attempts to stimulate this process pharmacologically have so far been unsuccessful, but might in the future be a target of weight loss therapy.

GeneticsEdit

In 2007, researchers isolated the adipose gene, which ap­par­ently serves to keep animals lean dur­ing times of plen­ty. Increased adipose gene activity was associated with slimmer individuals.[6]

Physical propertiesEdit

Adipose tissue has a density of ~0.9g/ml [7]. Thus, a person with much adipose tissue will float easier than a person with lot of muscular tissue, since muscular tissue has a density of 1.06 g/ml[7].

Cultural and social roleEdit

File:Excess human adipose tissue.jpg

Excess adipose tissue on a human can lead to medical problems; however, a round or large figure does not of itself imply a medical problem, and is sometimes not primarily caused by adipose tissue. For a discussion of the aesthetic and medical significance of body shape, see dieting and obesity.


Additional imagesEdit

ReferencesEdit

  1. Pond, Caroline M. (1998). The Fats of Life. Cambridge University Press. ISBN 0521635772. 
  2. Himms-Hagen, J. (August 1990) "Brown adipose tissue thermogenesis: interdisciplinary studies" The FASEB Journal (Federation of American Societies for Experimental Biology) 4(11): pp. 2890-2898
  3. Suh, Jae Myoung et al. (September 2007) "Adipose Is a Conserved Dosage-Sensitive Antiobesity Gene" Cell Me­tab­o­lism 6(3): pp. 195-207
  4. 7.0 7.1 Google Answers: Muscle Density vs. Fat Density
  1. Bachmanov AA, Reed DR, Tordoff MG, Price RA, Beauchamp GK (2001) Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice. Physiology and Behavior 72, 603-613
  2. Cinti S (1999) The adipose organ. Editrice Kurtis, Milano
  3. Pond CM (1998) The fats of life. Cambridge University Press, Cambridge

See alsoEdit


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